Retatrutide vs Semaglutide
Retatrutide is a GLP-1 / GIP / glucagon triple-agonist. Semaglutide is a single-target GLP-1 receptor agonist. They sit at different points on the receptor-coverage spectrum.
Research Use Only
Comparison information is provided for in-vitro research reference only. Orion compounds are not FDA-approved and are not for human consumption.
| Retatrutide | Semaglutide | |
|---|---|---|
| CAS Number | 2381089-83-2 | 910463-68-2 |
| Molecular Weight | 4625.27 g/mol | 4113.58 g/mol |
| Sequence | — | — |
| Purity (spec) | 99.0% | 98.9% |
| Size | 10mg | 10mg |
| Half-Life (lit.) | 144h (lit. 120h–168h) | 165h (lit. 155h–184h) |
| Single price | $54.99 | $39.99 |
| 10-pack/vial | $41.24 | $29.99 |
| In stock? | Yes | Yes |
Metabolic Signaling Research
Retatrutide
Triple agonist peptide. GLP-1/GIP/Glucagon receptor activity. 10mg research vial.
Metabolic Signaling Research
Semaglutide
GLP-1 receptor agonist peptide. 31 amino acid modified sequence. 10mg research vial.
FAQ
What's the chemical difference between Retatrutide and Semaglutide?
Retatrutide (CAS 2381089-83-2, MW 4625.27 g/mol) and Semaglutide (CAS 910463-68-2, MW 4113.58 g/mol) are distinct compounds. Retatrutide is a GLP-1 / GIP / glucagon triple-agonist. Semaglutide is a single-target GLP-1 receptor agonist. They sit at different points on the receptor-coverage spectrum.
Which is more commonly used in research?
Both Retatrutide and Semaglutide appear extensively in GLP-1-class research compounds literature. Comparative-mechanism studies frequently use them as paired references. Selection between them depends on the receptor coverage, kinetics, and assay system of the planned experiment.
What purity does Orion ship for each?
Retatrutide ships at 99.0%. Semaglutide ships at 98.9%. Each batch is independently tested by reversed-phase HPLC and confirmed by mass spectrometry against the theoretical molecular weight. Every order ships with a batch-specific Certificate of Analysis.
Are these for human use?
No. All Orion research compounds are for in-vitro laboratory research only. They are not FDA-approved for any therapeutic, diagnostic, or clinical use, and they are not for human consumption.