Semaglutide — Research Guide
Semaglutide is a single-target GLP-1 receptor agonist peptide and the canonical reference compound for GLP-1-receptor research. As the longest-running modern GLP-1 analogue with extensive literature, it serves as the baseline against which newer dual- and triple-agonists are compared.
Research Use Only — Not FDA-Approved
Orion compounds are for in-vitro laboratory research only and are not for human consumption.
Product
Semaglutide 10mg
Purity
98.9%
CAS
910463-68-2
Single
$39.99
10-pack/vial
$29.99
Chemistry & identity
Semaglutide (CAS 910463-68-2, MW 4113.58 g/mol) is a 31-amino-acid modified GLP-1 analogue with a C18 fatty-diacid conjugated via a γ-Glu-OEG-OEG linker. The fatty-acid modification confers prolonged in-solution persistence and albumin-binding behavior in published assays.
Research applications
- Pure GLP-1R agonism (no GIP, no glucagon co-activation)
- Albumin-binding kinetics of fatty-acid-conjugated peptides
- β-cell signaling pathway studies in islet preparations
- Receptor-desensitization and internalization assays
- Comparative pharmacology baseline for incretin-class research
Stability & storage
Lyophilized Semaglutide is stable at −20°C protected from light. Reconstituted material is typically refrigerated. The fatty-acid linker contributes to extended in-solution stability vs unconjugated GLP-1.
Published half-life range
165h midpoint (lit. 155h – 184h)
Source: Knudsen et al., J Med Chem 2019. See the half-life calculator for predicted in-solution decay over time.
Direct comparisons
Related research guides
Retatrutide — Research Guide
Retatrutide is an investigational triple-agonist peptide that binds the GLP-1, GIP, and glucagon receptors. It is one of the most cited compounds in current incretin-class metabolic-signaling research and is studied alongside earlier dual and single agonists (Tirzepatide, Semaglutide) to isolate the contribution of glucagon co-agonism.
Tirzepatide — Research Guide
Tirzepatide is a dual GIP / GLP-1 receptor agonist peptide. It is widely used in incretin-class metabolic-signaling research as the reference dual-agonist control alongside single-target agonists (Semaglutide) and triple-target agonists (Retatrutide).
FAQ
Is Semaglutide the same as Ozempic?
Semaglutide is the synthetic peptide. Branded clinical products are reference points only — Orion supplies the research material; we make no claims about equivalence to clinical formulations and the product is not for human use.
Why is the fatty-acid modification on Semaglutide important?
The C18 diacid + γ-Glu-OEG-OEG linker drives albumin binding, which extends the in-solution half-life dramatically vs unconjugated GLP-1. It's a textbook example of peptide PK-engineering for research-design purposes.
What purity does Orion ship?
≥ 98.9% by reversed-phase HPLC, with the measured value recorded on the batch-specific COA.
Is this for human use?
No. In-vitro research use only. Not FDA-approved.