MOTS-c — Research Guide
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded by the mitochondrial 12S ribosomal RNA. It is a foundational compound in cellular and mitochondrial signaling research and is studied in metabolic-pathway and AMPK-axis literature.
Research Use Only — Not FDA-Approved
Orion compounds are for in-vitro laboratory research only and are not for human consumption.
Product
MOTS-c 10mg
Purity
98.9%
CAS
1627580-64-6
Single
$26.99
10-pack/vial
$20.24
Chemistry & identity
MOTS-c (CAS 1627580-64-6, MW 2174.67 g/mol) is unusual among research peptides in that it is encoded entirely within mitochondrial DNA rather than the nuclear genome. Per-batch HPLC + MS verification on every Orion lot.
Research applications
- AMPK pathway activation and downstream metabolic signaling
- Mitochondrial-to-nuclear retrograde signaling research
- Insulin-sensitivity assay models
- Mitochondrial-derived-peptide (MDP) class characterization
- Comparative studies with other mitochondrial peptides (humanin, SHLPs)
Stability & storage
Lyophilized MOTS-c is stable at −20°C. Plasma half-life of the free peptide in published research is short (minutes); in-solution stability in standard buffers is longer but should be assayed before extended timecourse work.
Published half-life range
15 min midpoint (lit. 0.15h – 0.5h)
Source: Lee et al., Cell Metab 2015. See the half-life calculator for predicted in-solution decay over time.
Direct comparisons
Related research guides
FAQ
How is MOTS-c different from a 'nuclear' peptide?
MOTS-c is encoded by mitochondrial DNA (specifically the 12S rRNA region). This makes it one of a small class of mitochondrial-derived peptides studied as retrograde signaling messengers from the mitochondrion to the rest of the cell.
Why is the half-life so short?
As a free peptide, MOTS-c is rapidly cleared from plasma in published animal-model studies. Tissue half-life varies. The half-life calculator uses the published plasma midpoint of ~15 minutes.
What purity does Orion ship?
≥ 98.9% by reversed-phase HPLC, batch-specific value on the COA.
Is this for human use?
No. In-vitro research use only.