Tesamorelin — Research Guide
Tesamorelin is a synthetic growth-hormone-releasing-hormone (GHRH) analogue carrying a trans-3-hexenoic acid modification on the N-terminus. It is studied as the reference GHRH analogue in growth-hormone-secretagogue receptor research and is one of the most-cited modified-GHRH compounds in modern endocrinology literature.
Research Use Only — Not FDA-Approved
Orion compounds are for in-vitro laboratory research only and are not for human consumption.
Product
Tesamorelin 10mg
Purity
99.0%
CAS
804475-66-9
Single
$44.99
10-pack/vial
$33.74
Chemistry & identity
Tesamorelin (CAS 804475-66-9, MW 5135.89 g/mol) is a 44-residue peptide. The N-terminal trans-3-hexenoic acid modification confers protease resistance and extended in-solution stability vs native GHRH(1-44).
Research applications
- GHRH-receptor binding and selectivity research
- Modified-GHRH structure-activity studies
- Comparative pharmacology against native GHRH and other analogues
- Pituitary somatotroph cell-culture timecourse assays
- N-terminal modification chemistry for protease resistance
Stability & storage
Lyophilized Tesamorelin is stable at −20°C. As a longer peptide it benefits from gentle reconstitution to avoid aggregation; published research typically uses bacteriostatic water and immediate refrigeration.
Published half-life range
27 min midpoint (lit. 0.3h – 0.7h)
Source: Falutz et al., NEJM 2007. See the half-life calculator for predicted in-solution decay over time.
FAQ
How is Tesamorelin different from native GHRH?
Native GHRH(1-44) has a very short plasma half-life and is rapidly degraded. Tesamorelin's N-terminal trans-3-hexenoic acid modification slows degradation and extends in-solution stability in published research.
What's the in-solution half-life?
Short in plasma (~27 minutes per published clinical pharmacology). See the half-life calculator for the decay model.
What purity does Orion ship?
≥ 99.0% by reversed-phase HPLC, batch-specific value on the COA.
Is this for human use?
No. In-vitro research use only.